产品名称
FBW1B Rabbit Polyclonal Antibody
基因名称
FBXW11 BTRCP2 FBW1B FBXW1B KIAA0696
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23291
Human Swissprot No.
Q9UKB1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UKB1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/103583
Mouse Swissprot No.
Q5SRY7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5SRY7
免疫原
Synthesized peptide derived from human FBW1B AA range: 464-514
特异性
This antibody detects endogenous levels of FBW1B at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Nucleus .
功能
function:Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of NFKBIA, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1.,similarity:Contains 1 F-box domain.,similarity:Contains 7 WD repeats.,subunit:Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1A, RBX1 and a FBXW11 dimer. Interacts with BTRC. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1; the interaction requires the phosphorylation of the two serine residues in the destruction motif D-S-G-X(2,3)-S.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
