产品名称
OST48 Rabbit Polyclonal Antibody
基因名称
DDOST KIAA0115 OST48 OK/SW-cl.45
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1650
Human Swissprot No.
P39656
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P39656/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13200
Mouse Swissprot No.
O54734
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O54734
Rat Gene Link
https://www.uniprot.org/uniprot/313648
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q641Y0
免疫原
Synthesized peptide derived from human OST48 AA range: 54-104
特异性
This antibody detects endogenous levels of OST48 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008],
细胞定位
Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
功能
catalytic activity:Dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-glycosyl linkage to protein L-asparagine.,caution:It is uncertain whether Met-1 or Met-18 is the initiator.,function:Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the DDOST 48 kDa subunit family.,subunit:Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes even after release from the ribosome.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
