产品名称
PAK6 Rabbit Polyclonal Antibody
蛋白名称
Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NQU5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NQU5/entry
Mouse Swissprot No.
Q3ULB5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3ULB5
免疫原
Synthesized peptide derived from human protein . at AA range: 100-180
特异性
PAK6 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
组织表达
Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.
细胞定位
Cytoplasm. Nucleus. Cotranslocates into nucleus with AR in response to androgen induction.
信号通路
ErbB_HER;Axon guidance;Focal adhesion;T_Cell_Receptor;Regulates Actin and Cytoskeleton;Renal cell carcinoma;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:The activated kinase acts on a variety of targets.,PTM:Autophosphorylated when activated by CDC42/p21.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
