产品名称
ADR1 Rabbit Polyclonal Antibody
基因名称
ADIPOR1 PAQR1 TESBP1A CGI-45
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51094
Human Swissprot No.
Q96A54
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96A54/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72674
Mouse Swissprot No.
Q91VH1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91VH1
免疫原
Synthesized peptide derived from human ADR1 AA range: 277-327
特异性
This antibody detects endogenous levels of ADR1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014],
组织表达
Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).
细胞定位
Cell membrane ; Multi-pass membrane protein . Localized to the cell membrane and intracellular organelles. .
功能
function:Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.,similarity:Belongs to the ADIPOR family.,subcellular location:Localized to the cell membrane and intracellular organelles.,subunit:May form homo and heteromultimers.,tissue specificity:Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
