产品名称
APBB3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10307
Human Swissprot No.
O95704
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95704/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/225372
Mouse Swissprot No.
Q8R1C9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R1C9
Rat Gene Link
https://www.uniprot.org/uniprot/117026
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O35827
免疫原
Synthesized peptide derived from human APBB3 AA range: 403-453
特异性
This antibody detects endogenous levels of APBB3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed in various tissues, highest expression in brain.
细胞定位
Cytoplasm . Nucleus .; [Isoform I-214]: Nucleus.; [Isoform I-245]: Nucleus.
功能
function:May modulate the internalization of beta-amyloid precursor protein.,similarity:Contains 1 WW domain.,similarity:Contains 2 PID domains.,subunit:Binds to the intracellular domain of the beta-amyloid precursor protein. Also bind to APP-like proteins.,tissue specificity:Expressed in various tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
