产品名称
BRD1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23774
Human Swissprot No.
O95696
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95696/entry
免疫原
Synthesized peptide derived from human BRD1 AA range: 399-449
特异性
This antibody detects endogenous levels of BRD1 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schozophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],
组织表达
Highly expressed in testis.
细胞定位
Nucleus . Chromosome . Localizes to transcription start sites. .
功能
function:Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.,similarity:Contains 1 bromo domain.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 PWWP domain.,subunit:Component of the MOZ/MORF composed at least of ING5, MYST3/MOZ, MYST4/MORF and one of BRPF1, BRD1/BRPF2 and BRPF3.,tissue specificity:Highly expressed in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
