产品名称
TPM4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7171
Human Swissprot No.
P67936
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P67936/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/326618
Mouse Swissprot No.
Q6IRU2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6IRU2
Rat Gene Link
https://www.uniprot.org/uniprot/24852
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P09495
免疫原
Synthesized peptide derived from human TPM4 AA range: 127-177
特异性
This antibody detects endogenous levels of TPM4 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009],
组织表达
Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).
细胞定位
Cytoplasm, cytoskeleton . Associates with F-actin stress fibers. .
功能
domain:The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.,function:Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.,similarity:Belongs to the tropomyosin family.,subunit:Heterodimer of an alpha and a beta chain.,tissue specificity:Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
