产品名称
WDR82 Rabbit Polyclonal Antibody
基因名称
WDR82 WDR82A UNQ9342/PRO34047
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/80335
Human Swissprot No.
Q6UXN9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6UXN9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/77305
Mouse Swissprot No.
Q8BFQ4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BFQ4
免疫原
Synthesized peptide derived from human WDR82 AA range: 219-269
特异性
This antibody detects endogenous levels of WDR82 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010],
细胞定位
Nucleus . Chromosome . Associates with chromatin (PubMed:20516061). Recruited at sites of high RNA polymerase II occupancy (By similarity). .
功能
caution:The gene encoding this protein shares one overlapping exon with TMEM113.,function:Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3.,similarity:Belongs to the WD repeat SWD2 family.,similarity:Contains 6 WD repeats.,subunit:Interacts with CUL4B. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
