产品名称
PC11X Rabbit Polyclonal Antibody
基因名称
PCDH11X KIAA1326 PCDH11 PCDHX
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/27328
Human Swissprot No.
Q9BZA7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BZA7/entry
免疫原
Synthesized peptide derived from human PC11X AA range: 836-886
特异性
This antibody detects endogenous levels of PC11X at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Disruption of this gene may be associated with developmental dyslexia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
组织表达
Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
alternative products:Additional isoforms seem to exist,function:Potential calcium-dependent cell-adhesion protein.,similarity:Contains 7 cadherin domains.,tissue specificity:Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
