产品名称
GALC Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2581
Human Swissprot No.
P54803
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P54803/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14420
Mouse Swissprot No.
P54818
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P54818
免疫原
Synthesized peptide derived from human GALC AA range: 481-531
特异性
This antibody detects endogenous levels of GALC at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
组织表达
Detected in urine. Detected in testis, brain and placenta (at protein level). Detected in kidney and liver.
功能
catalytic activity:D-galactosyl-N-acylsphingosine + H(2)O = D-galactose + N-acylsphingosine.,caution:It is uncertain whether Met-1 or Met-17 is the initiator.,disease:Defects in GALC are the cause of leukodystrophy globoid cell (GLD) [MIM:245200]; also known as Krabbe disease. This autosomal recessive disorder results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin. Clinically, the most frequent form is the infantile form. Most patients (90%) present before six months of age with irritability, spasticity, arrest of motor and mental development, and bouts of temperature elevation without infection. This is followed by myoclonic jerks of arms and legs, oposthotonus, hypertonic fits, and mental regression, which progresses to a severe decerebrate condition with no voluntary movements and death from respiratory infections or cerebral hyperpyrexia before 2 years of age. However, a significant number of cases with later onset, presenting with unexplained blindness, weakness and/or progressive motor, and sensory neuropathy that can progress to severe mental incapacity and death, have been identified.,function:Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.,online information:Krabbe disease website,polymorphism:Polymorphic amino-acid changes are responsible for the wide range of catalytic activities found in the general population.,similarity:Belongs to the glycosyl hydrolase 59 family.,tissue specificity:Highest level of activity in testes compared to brain, kidney, placenta and liver. Can also be found in urine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
