产品名称
DZIP1 Rabbit Polyclonal Antibody
基因名称
DZIP1 DZIP DZIP2 KIAA0996
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/22873
Human Swissprot No.
Q86YF9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86YF9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66573
Mouse Swissprot No.
Q8BMD2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BMD2
免疫原
Synthesized peptide derived from human DZIP1 AA range: 73-123
特异性
This antibody detects endogenous levels of DZIP1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Predominantly expressed in testis (at protein level) (PubMed:15081113, PubMed:32051257). Also expressed in fetal brain, adult oocytes and ovary (PubMed:15081113). Expressed in undifferentiated ES cells (PubMed:15081113). In testis, it is specifically expressed in germ cells (at protein level) (PubMed:15081113, PubMed:32051257). Expressed in mature germ cells and secondary spermatocytes, while it is weakly or not expressed in primary spermatocytes (PubMed:15081113).
细胞定位
Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Nucleus . Nucleus speckle . Cytoplasm . Localizes to the centriole in cells lacking cilia and to the cilium basal body in ciliated cells (PubMed:19852954). At the exit of mitosis, when the primary cilium is reassembled in daughter cells, localizes at the mother centriole that acts as the basal body of the assembling primary cilium and also accumulates at the ciliary base that constitutes a diffusion barrier for ciliary proteins (By similarity). .
功能
function:May participate in spermatogenesis via its interaction with DAZ.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the DZIP C2H2-type zinc-finger protein family.,similarity:Contains 1 C2H2-type zinc finger.,subcellular location:In testis, it is predominantly nuclear, with some cytoplasmic localization in spermatogonia. Colocalizes with DAZ and DAZL in primordial germ cells.,subunit:Isoform 1 and isoform 2 interact with DAZ proteins. May participate in a RNA-binding complex that functions in both ES cells and germ cells.,tissue specificity:Predominantly expressed in testis. Also expressed in fetal brain, adult oocytes and ovary. Expressed in undifferentiated ES cells. In testis, it is probably specifically expressed in germ cells. Expressed in mature germ cells and secondary spermatocytes, while it is weakly or not expressed in primary spermatocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
