产品名称
RGS19 Rabbit Polyclonal Antibody
蛋白名称
Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P49795
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49795/entry
Mouse Swissprot No.
Q9CX84
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CX84
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O70521
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
RGS19 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
细胞定位
Membrane; Lipid-anchor.
功能
function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,PTM:Phosphorylated, mainly on serine residues.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIPC PDZ domain.,tissue specificity:Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
