产品名称
CYH4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/27128
Human Swissprot No.
Q9UIA0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UIA0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72318
Mouse Swissprot No.
Q80YW0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80YW0
免疫原
Synthesized peptide derived from human CYH4 AA range: 150-200
特异性
This antibody detects endogenous levels of CYH4 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015],
组织表达
Expressed predominantly in peripheral blood leukocytes.
细胞定位
Cell membrane ; Peripheral membrane protein .
功能
function:Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,tissue specificity:Expressed predominantly in peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
