产品名称
URGCP Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55665
Human Swissprot No.
Q8TCY9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TCY9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72046
Mouse Swissprot No.
Q5NCI0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5NCI0
免疫原
Synthesized peptide derived from human URGCP AA range: 345-395
特异性
This antibody detects endogenous levels of URGCP at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008],
组织表达
Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.
细胞定位
Cytoplasm . Nucleus . In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.
功能
function:May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.,induction:By HBxAg. Up-regulated in gastric cancer tissues and also in gastric cancer cell lines (at protein level).,sequence caution:Translation N-terminally extended.,subcellular location:In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.,tissue specificity:Strongly expressed in hepatitis B-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
