产品名称
SH3G1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6455
Human Swissprot No.
Q99961
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99961/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20405
Mouse Swissprot No.
Q62419
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q62419
Rat Gene Link
https://www.uniprot.org/uniprot/81922
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O35964
免疫原
Synthesized peptide derived from human SH3G1 AA range: 112-162
特异性
This antibody detects endogenous levels of SH3G1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],
组织表达
Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.
细胞定位
Cytoplasm . Early endosome membrane ; Peripheral membrane protein . Cell projection, podosome . Associated with postsynaptic endosomes in hippocampal neurons. .
功能
disease:In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene.,domain:An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.,function:Implicated in endocytosis. May recruit other proteins to membranes with high curvature.,similarity:Belongs to the endophilin family.,similarity:Contains 1 BAR domain.,similarity:Contains 1 SH3 domain.,subcellular location:Associated with postsynaptic endosomes in hippocampal neurons.,subunit:Interacts with ARC (By similarity). Interacts with SYNJ1 and DNM1. Interacts with PDCD6IP.,tissue specificity:Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
