产品名称
DBR1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51163
Human Swissprot No.
Q9UK59
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UK59/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/83703
Mouse Swissprot No.
Q923B1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q923B1
免疫原
Synthesized peptide derived from human DBR1 AA range: 230-280
特异性
This antibody detects endogenous levels of DBR1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011],
组织表达
Ubiquitously expressed, strongest expression in the spinal cord and brainstem.
功能
catalytic activity:RNA processing activity that hydrolyzes the 2'-5' phosphodiester linkage at the branchpoint of excised intron lariats.,cofactor:Divalent metal cations.,function:Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via a RNA lariat intermediate in cDNA synthesis.,miscellaneous:Cells lacking DBR1 show an inhibition of HIV-1 replication.,similarity:Belongs to the lariat debranching enzyme family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
