产品名称
PRAF3 Rabbit Polyclonal Antibody
基因名称
ARL6IP5 DERP11 JWA PRA2 PRAF3 HSPC127
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10550
Human Swissprot No.
O75915
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75915/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/65106
Mouse Swissprot No.
Q8R5J9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R5J9
Rat Gene Link
https://www.uniprot.org/uniprot/66028
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ES40
免疫原
Synthesized peptide derived from human PRAF3 AA range: 120-170
特异性
This antibody detects endogenous levels of PRAF3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008],
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cytoplasm, cytoskeleton . Also exists as a soluble form in the cytoplasm. Associated with microtubules. .
功能
function:Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic.,induction:By methyl-beta-cyclodextrin (By similarity). Up-regulated upon induced differentiation and in heat stress.,similarity:Belongs to the PRA1 family.,subcellular location:Also exists as a soluble form in the cytoplasm. Associated with microtubules.,subunit:Forms multimers. Binds to prenylated RAB1A and RAB3A, to the neuronal glutamate transporter SLC1A1/EAAC1, and to the ADP-ribosylation like factor ARL6, a member of the Ras superfamily. Does not bind to VAMP2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
