产品名称
KHK Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3795
Human Swissprot No.
P50053
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P50053/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16548
Mouse Swissprot No.
P97328
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97328
Rat Gene Link
https://www.uniprot.org/uniprot/25659
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q02974
免疫原
Synthesized peptide derived from human KHK AA range: 102-152
特异性
This antibody detects endogenous levels of KHK at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
组织表达
Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.
细胞定位
cytoplasm,cytosol,extracellular exosome,
功能
catalytic activity:ATP + D-fructose = ADP + D-fructose 1-phosphate.,caution:Form C has not yet been fully sequenced in its N-terminal (from 1-69).,disease:Defects in KHK are the cause of fructosuria [MIM:229800]. Fructosuria is a benign defect of intermediary metabolism.,enzyme regulation:Requires potassium. Inhibition by ADP.,pathway:Carbohydrate metabolism; fructose metabolism.,similarity:Belongs to the carbohydrate kinase pfkB family.,subunit:Dimer of A-A, A-C or C-C.,tissue specificity:Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
