产品名称
GBRAP Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11337
Human Swissprot No.
O95166
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95166/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56486
Mouse Swissprot No.
Q9DCD6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DCD6
Rat Gene Link
https://www.uniprot.org/uniprot/58974
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P60517
免疫原
Synthesized peptide derived from human GBRAP AA range: 8-58
特异性
This antibody detects endogenous levels of GBRAP at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008],
组织表达
Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
细胞定位
Cytoplasmic vesicle, autophagosome membrane . Endomembrane system . Cytoplasm, cytoskeleton . Golgi apparatus membrane . Cytoplasmic vesicle . Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). .
功能
function:May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.,similarity:Belongs to the MAP1 LC3 family.,subcellular location:Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules.,subunit:Interacts with GPHN and NSF (By similarity). Interacts with GABRG2, beta-tubulin and ULK1.,tissue specificity:Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
