产品名称
PARG Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8505
Human Swissprot No.
Q86W56
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86W56/entry
Mouse Swissprot No.
O88622
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88622
Rat Gene Link
https://www.uniprot.org/uniprot/83507
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QYM2
免疫原
Synthesized peptide derived from human PARG AA range: 140-190
特异性
This antibody detects endogenous levels of PARG at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009],
组织表达
Ubiquitously expressed.
细胞定位
[Isoform 1]: Nucleus . Colocalizes with PCNA at replication foci (PubMed:21398629). Relocalizes to the cytoplasm in response to DNA damage (PubMed:16460818). .; [Isoform 2]: Cytoplasm . Translocates to the nucleus in response to DNA damage. .; [Isoform 3]: Cytoplasm .; [Isoform 4]: Cytoplasm . Mitochondrion .; [Isoform 5]: Mitochondrion matrix .
功能
function:Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes.,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,subunit:Monomer.,tissue specificity:Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
