产品名称
PRPC Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5554
Human Swissprot No.
P02810
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P02810/entry
免疫原
Synthesized peptide derived from human PRPC AA range: 81-131
特异性
This antibody detects endogenous levels of PRPC at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015],
功能
function:PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.,online information:The Singapore human mutation and polymorphism database,polymorphism:Sequence shown is that of allele PRH2-2, also known as PR-2; Allele PRH2-1 is also known as PR-1 or protein C, and allele PRH2-3 as PR-1'. The PRH1-DB allele (about 16% of the population) has an insertion of 21 repeated amino-acids compared to the more frequent PRH1-PIF allele (68%). In contrast to all other PRH1 and PRH2 alleles, the PRH1-PA allele (16%) is not proteolytically cleaved.,PTM:An hexuronic acid was shown to be linked to Ser-33 in about 40% of the polypeptides. Neither the structure of the carbohydrate (whether glucuronic acid or an isomer of), nor the linkage (whether a glycoside or an ester) has been definitely established.,PTM:Proteolytically cleaved; PRP-2, PRP-1, PIF-S and Db-S yield PRP-4, PRP-3 (protein A), PIF-F and Db-F, respectively.,sequence caution:Translated as stop.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
