产品名称
BAIP3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8938
Human Swissprot No.
O94812
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O94812/entry
Mouse Swissprot No.
Q80TT2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80TT2
免疫原
Synthesized peptide derived from human BAIP3 AA range: 248-298
特异性
This antibody detects endogenous levels of BAIP3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],
组织表达
Predominantly expressed in brain (PubMed:9790924). Also expressed in nonneural tissues such as breast and testes epithelium (PubMed:12498718).
细胞定位
Cytoplasm, cytosol . Recycling endosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Rapidly recruited to the plasma membrane and to Golgi structures in response to increased intracellular calcium concentration. .
功能
similarity:Contains 1 MHD1 (MUNC13 homology domain 1) domain.,similarity:Contains 1 MHD2 (MUNC13 homology domain 2) domain.,similarity:Contains 2 C2 domains.,subunit:Interacts with BAI1.,tissue specificity:Predominantly expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.