产品名称
GSTM5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2949
Human Swissprot No.
P46439
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P46439/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14866
Mouse Swissprot No.
P48774
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P48774
Rat Gene Link
https://www.uniprot.org/uniprot/100912430
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z1B2
免疫原
Synthesized peptide derived from human GSTM5 AA range: 99-149
特异性
This antibody detects endogenous levels of GSTM5 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008],
功能
catalytic activity:RX + glutathione = HX + R-S-glutathione.,function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,similarity:Belongs to the GST superfamily.,similarity:Belongs to the GST superfamily. Mu family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
