产品名称
MAGI3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/260425
Human Swissprot No.
Q5TCQ9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5TCQ9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/99470
Mouse Swissprot No.
Q9EQJ9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EQJ9
Rat Gene Link
https://www.uniprot.org/uniprot/245903
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JK71
免疫原
Synthesized peptide derived from human MAGI3 AA range: 927-977
特异性
This antibody detects endogenous levels of MAGI3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
细胞定位
Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus . Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity). .
功能
function:Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.,miscellaneous:MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains.,PTM:Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 2 WW domains.,similarity:Contains 6 PDZ (DHR) domains.,subcellular location:Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions.,subunit:Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with unidentified tyrosine phosphorylated proteins (By similarity). Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection, interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3 proteins. In case of infection, interacts with HPV type 16 and HPV type 18 E6 protein.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
