产品名称
SHRM3 Rabbit Polyclonal Antibody
基因名称
SHROOM3 KIAA1481 SHRML MSTP013
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57619
Human Swissprot No.
Q8TF72
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TF72/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/27428
Mouse Swissprot No.
Q9QXN0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QXN0
免疫原
Synthesized peptide derived from human SHRM3 AA range: 777-827
特异性
This antibody detects endogenous levels of SHRM3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011],
细胞定位
Cell junction, adherens junction . Cytoplasm, cytoskeleton . Apical cell membrane ; Peripheral membrane protein . Colocalizes with F-actin in stress fibers and adherens junctions. .
功能
domain:The ASD1 domain mediates F-actin binding.,domain:The ASD2 domain is required for apical constriction induction.,function:Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays.,similarity:Belongs to the shroom family.,similarity:Contains 1 ASD1 domain.,similarity:Contains 1 ASD2 domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Colocalizes with F-actin in stress fibers and adherens junctions.,subunit:Interacts with F-actin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
