产品名称
VTA1 Rabbit Polyclonal Antibody
基因名称
VTA1 C6orf55 HSPC228 My012
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51534
Human Swissprot No.
Q9NP79
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NP79/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66201
Mouse Swissprot No.
Q9CR26
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CR26
免疫原
Synthesized peptide derived from human VTA1 AA range: 207-257
特异性
This antibody detects endogenous levels of VTA1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]).[supplied by OMIM, Mar 2008],
细胞定位
Cytoplasm . Endosome membrane ; Peripheral membrane protein .
功能
function:Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.,similarity:Belongs to the VTA1 family.,subunit:Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. May interact with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
