产品名称
EXOS2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23404
Human Swissprot No.
Q13868
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13868/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/227715
Mouse Swissprot No.
Q8VBV3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VBV3
免疫原
Synthesized peptide derived from human EXOS2 AA range: 90-140
特异性
This antibody detects endogenous levels of EXOS2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
细胞定位
Cytoplasm. Nucleus, nucleolus. Nucleus.
功能
function:Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3'-5' exonuclease activity.,similarity:Contains 1 S1 motif domain.,subunit:Component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: EXOSC1/CSL4, EXOSC2/RRP4, EXOSC3/RRP40, EXOSC4/RRP41, EXOSC5/RRP46, EXOSC6/MTR3, EXOSC7/RRP42, EXOSC8/RRP43, EXOSC9/Scl-75, DIS3/RRP44, and EXOSC10/Scl-100 (only in the nuclear complex). Found in a mRNA decay complex with RENT1, RENT2 and RENT3B. Also associated with the GTPase Ran.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
