产品名称
ASB3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51130
Human Swissprot No.
Q9Y575
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y575/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/65257
Mouse Swissprot No.
Q9WV72
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WV72
免疫原
Synthesized peptide derived from human ASB3 AA range: 30-80
特异性
This antibody detects endogenous levels of ASB3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011],
细胞定位
ubiquitin ligase complex,nucleus,cytoplasm,
功能
domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.,function:Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 SOCS box domain.,similarity:Contains 11 ANK repeats.,subunit:Interacts with TCEB2 and TNFRSF1B.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
