产品名称
SIA7D Rabbit Polyclonal Antibody
基因名称
ST6GALNAC4 SIAT3C SIAT7D
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/27090
Human Swissprot No.
Q9H4F1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H4F1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20448
Mouse Swissprot No.
Q9R2B6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R2B6
免疫原
Synthesized peptide derived from human SIA7D AA range: 194-244
特异性
This antibody detects endogenous levels of SIA7D at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
功能
catalytic activity:CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-D-galactosaminyl-R.,function:Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids.,online information:GlycoGene database,online information:ST6GalNAc IV,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 29 family.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
