产品名称
RSPO4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/343637
Human Swissprot No.
Q2I0M5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q2I0M5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/228770
Mouse Swissprot No.
Q8BJ73
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BJ73
免疫原
Synthesized peptide derived from human RSPO4 AA range: 43-93
特异性
This antibody detects endogenous levels of RSPO4 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009],
功能
disease:Defects in RSPO4 are the cause of anonychia [MIM:206800]. This is a rare autosomal recessive conditions in which the only presenting phenotype is the absence or severe hypoplasia of all fingernails and toenails.,domain:The FU repeat is required for activation and stabilization of beta-catenin.,function:Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors.,miscellaneous:Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis.,PTM:Tyr-112 may be phosphorylated; however as this position is probably extracellular, the vivo relevance is not proven.,similarity:Belongs to the R-spondin family.,similarity:Contains 1 FU (furin-like) repeat.,similarity:Contains 1 TSP type-1 domain.,subunit:Binds heparin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
